Peroxidação lipídica e inativação do óxido nítrico na pós-menopausa / Lipid peroxidation and nitric oxide inactivation in postmenopausal women
Arq. bras. cardiol
; Arq. bras. cardiol;80(4): 406-423, Apr. 2003. graf
Article
em Pt, En
| LILACS, SES-SP
| ID: lil-334405
Biblioteca responsável:
BR1.1
RESUMO
OBJECTIVE:
To assess the effect of endogenous estrogens on the bioavailability of nitric oxide ( NO) and in the formation of lipid peroxidation products in pre- and postmenopausal women.METHODS:
NOx and S-nitrosothiols were determined by gaseous phase chemiluminescence, nitrotyrosine was determined by ELISA, COx (cholesterol oxides) by gas chromatography, and cholesteryl linoleate hydroperoxides (CE182-OOH), trilinolein (TG182-OOH), and phospholipids (PC-OOH) by HPLC in samples of plasma.RESULTS:
The concentrations of NOx, nitrotyrosine, COx, CE182-OOH, and PC-OOH were higher in the postmenopausal period (33.8±22.3 mM; 230±130 nM; 55±19 ng/mL; 17±8.7 nM; 2775±460 nM, respectively) as compared with those in the premenopausal period (21.1±7.3 mM; 114±41 nM; 31±13 ng/mL; 6±1.4 nM; 1635±373 nM). In contrast, the concentration of S-nitrosothiols was lower in the postmenopausal period (91±55 nM) as compared with that in the premenopausal p in the premenopausal period (237±197 nM).CONCLUSION:
In the postmenopausal period, an increase in nitrotyrosine and a reduction of S-nitrosothiol formation, as well as an increase of COx, CE182-OOH and PC-OOH formation occurs. Therefore, òNO inactivation and the increase in lipid peroxidation may contribute to endothelial dysfunction and to the greater risk for atherosclerosis in postmenopausal women
Texto completo:
1
Índice:
LILACS
Assunto principal:
Peroxidação de Lipídeos
/
Pós-Menopausa
/
Estrogênios
/
Óxido Nítrico
Limite:
Adult
/
Female
/
Humans
Idioma:
En
/
Pt
Revista:
Arq. bras. cardiol
Assunto da revista:
CARDIOLOGIA
Ano de publicação:
2003
Tipo de documento:
Article