Neogénesis y regeneración de las células beta pancreáticas / Pancreatic beta-cell neogenesis and regeneration
Gac. méd. Méx
;
138(6): 557-564, Nov.-Dec. 2002.
Artigo
em Espanhol
| LILACS
| ID: lil-334526
ABSTRACT
OBJECTIVE: To review the literature on beta-cell neogenesis and regeneration, with special interest in substances that regulate such processes. DESIGN: Representative papers were selected through a computer MEDLINE search from 1990 to 2000. RESULTS: Several studies showed that once islets of Langerhans developed from small pancreatic ducts, this process did not continue in normal adult individuals. However, it has been published that new beta-cell formation can occur in vivo in certain experimental models through neogenesis, in which gene pax 4 is extremely important. On the other hand, substances that stimulate the regenerative process of beta-cells include glucose, several hormones and certain growth factors. CONCLUSIONS: Substances that stimulate the regenerative process commonly express this effect in elevated, non-physiologic concentrations; thus, their possible therapeutic importance is not yet clear. Nevertheless, the Reg protein, present in regenerative pancreas and implied in neogenesis process, has actual possibilities of becoming therapeutically important.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Ilhotas Pancreáticas
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Espanhol
Revista:
Gac. méd. Méx
Assunto da revista:
Medicina
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
México
Instituição/País de afiliação:
Instituto Mexicano del Seguro Social/MX
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