Plasmaféresis en el síndrome de Guillain-Barré / Plasmapheresis in Guillain-Barre syndrome
Gac. méd. Méx
;
138(6): 527-531, Nov.-Dec. 2002.
Artigo
em Espanhol
| LILACS
| ID: lil-334529
ABSTRACT
OBJECTIVE:
To evaluate the efficacy of early therapeutic plasmapheresis in severely affected patients with Guillain-BarrÚ syndrome (GBS). PATIENTS ANDMETHOD:
Patients between 16 to 70 years of age, with GBS according to NINCDS criteria, in stage > or = 3 of Huges severity score and with less than 7 days of onset of symptoms were admitted for therapeutic plasmapheresis. All patients completed a total of five sessions of plasma exchange every other day using 25 albumin and saline in a 11 proportion. Follow-up was performed for 6 months. Friedman and Wilcoxon tests were done to establish differences within groups.RESULTS:
A total of 34 patients were admitted to the study. The time span between onset of symptoms and admission to the study was 4 days (median). Fourteen (41) required mechanical ventilation. Clinical progression of the syndrome was observed during the first two sessions of plasma-pheresis. Improvement in motor function by Huges score was observed only after fourth session of plasma exchange (p < 0.05). Two patients did not improve, and one died.CONCLUSIONS:
Clinical improvement in GBS during early therapeutic plasmapheresis occurs only after the fourth session of plasma exchange.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Plasmaferese
/
Síndrome de Guillain-Barré
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Gac. méd. Méx
Assunto da revista:
Medicina
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
México
Instituição/País de afiliação:
Instituto Mexicano del Seguro Social/MX
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