Animal model of renal ischemic injury, and chlorpromazine protector effect, evaluated by TC-99M-Mag, dynamic renal scan
Acta cir. bras
;
17(supl.3): 15-19, 2002. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-335011
RESUMO
Acute tubular necrosis(ATN) is a major complication of kidney transplantation, so as of urologic and vascular surgeries. In transplantation, although organ oerfusion with proper solution are feasible and at least partially effective, new approaches remains needed to avoid lost of graft function due to ischemic insults, an by this way, chlorpromazine may play this hole. Sixteen male reats were evaluated by scintigraphy (dynamic renal scan with Tc-99m-MAG3), before and after surgically promote ischemia of left kidney. Animals were divided in 3 groups: Group A (control) without ischemic insult; Group B (ischemia without chlorpromazine) and Group C (ischemia with chlorpromazine). Group B demonstrated marked decreased of left renal function, compared with itself (right kidney; p<0,001) and compared with groups A and C (both p<0,001). No statistically observations was noted in group A, that makes sure of non-error source of surgical procedure lonely (p<0,05). Nevertheless mild decrease of left renal function was observed in some animals of group C, these appointments were not statistically significant (p<0,05). Further studies may prove, in the future, its usefulness in humans, specially concerning kidney transplantation.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Clorpromazina
/
Modelos Animais de Doenças
/
Insuficiência Renal
/
Isquemia
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade de São Paulo/BR
Similares
MEDLINE
...
LILACS
LIS