Fragility in the 14q21q translocation region
Genet. mol. biol
;
25(3): 271-276, Sept. 2002. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-335765
ABSTRACT
Aphidicolin (APC)-induced chromosomal breakage was analyzed for women representing three generations of a single family and carrying a Robertsonian translocation rob(14q21q). Fluorescence in situ hybridization (FISH) analysis confirmed the dicentric constitution of the derived chromosome and indicated the absence of beta-satellite signal at the translocation region. Per-individual analysis of metaphases from APC-treated peripheral blood lymphocyte cultures identified significantly nonrandom chromosomal breakage at the translocation region in all three individuals examined. The APC-inducible fragility at the 14q21q translocation region suggests that this rearrangement was the result of chromosomal mutation at fragile site(s) in the progenitor chromosomes, or that this fragility was the result of the fusion of nonfragile progenitor chromosomes
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Translocação Genética
/
Cromossomos Humanos Par 14
/
Cromossomos Humanos Par 21
/
Fragilidade Cromossômica
/
Afidicolina
/
Hibridização in Situ Fluorescente
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Genet. mol. biol
Assunto da revista:
Genética
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
Estados Unidos
Instituição/País de afiliação:
Texas A&M University/US
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