CD8+T cell abnormalities in scleroderma lung disease
Rev. chil. reumatol
; 18(3): 87-87, 2002.
Article
em En
| LILACS
| ID: lil-340235
Biblioteca responsável:
CL1.1
ABSTRACT
These data are consistent an important role for CD8+T cells in the completex pathology of lung fibrosis in scleroderma. These cels are increased in number, are activated, appear to have undergone initial selection by antigen stimulation, with increased oligoclonality, and have n unusual phenotype for CD8+T cells, that of production of type 2 cytokines. Cytolytic pathways appear to be engaged. These CD8+T cells may persist in vivo because of reduced activation-induced cell death. The cytokines and growth factors that they produce may directly stimulate extracellular matrix production
Texto completo:
1
Índice:
LILACS
Assunto principal:
Fibrose Pulmonar
/
Linfócitos T CD8-Positivos
Limite:
Humans
Idioma:
En
Revista:
Rev. chil. reumatol
Assunto da revista:
REUMATOLOGIA
Ano de publicação:
2002
Tipo de documento:
Article