Enalapril altera a formação da matriz colágena do miocárdio de ratos espontaneamente hipertensos / Enalapril alters the formation of the collagen matrix in spontaneously hypertensive rats
Arq. bras. cardiol
;
81(1): 64-72, July 2003. ilus, tab, graf
Artigo
em Português, Inglês
| LILACS
| ID: lil-341304
RESUMO
OBJECTIVE:
To assess the effect of the inhibition of the angiotensin-converting enzyme on the collagen matrix (CM) of the heart of newborn spontaneously hypertensive rats (SHR) during embryonic development.METHODS:
The study comprised the 2 following groups of SHR (n=5 each) treated group - rats conceived from SHR females treated with enalapril maleate (15 mg. kg-1.day-1) during gestation; and nontreated group - offspring of nontreated females. The newborns were euthanized within the first 24 hours after birth and their hearts were removed and processed for histological study. Three fields per animal were considered for computer-assisted digital analysis and determination of the volume densities (Vv) of the nuclei and CM. The images were segmented with the aid of Image Pro Plus® 4.5.029 software (Media Cybernetics).RESULTS:
No difference was observed between the treated and nontreated groups in regard to body mass, cardiac mass, and the relation between cardiac and body mass. A significant reduction in the Vv[matrix] and a concomitant increase in the Vv[nuclei] were observed in the treated group as compared with those in the nontreated group.CONCLUSION:
The treatment with enalapril of hypertensive rats during pregnancy alters the collagen content and structure of the myocardium of newborns
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Inibidores da Enzima Conversora de Angiotensina
/
Enalapril
/
Colágeno
/
Matriz Extracelular
/
Coração
Limite:
Animais
/
Gravidez
Idioma:
Inglês
/
Português
Revista:
Arq. bras. cardiol
Assunto da revista:
Cardiologia
Ano de publicação:
2003
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade do Estado do Rio de Janeiro/BR
Similares
MEDLINE
...
LILACS
LIS