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Detection of testicular cancer in men presenting with infertility
Pasqualotto, Fabio Firmbach; Pasqualotto, Eleonora Bedin; Agarwal, Ashok; Thomas Júnior, Anthony Joseph.
  • Pasqualotto, Fabio Firmbach; Urological Institute. Center for Advanced Research in Human Reproduction and Infertility. Cleveland. US
  • Pasqualotto, Eleonora Bedin; Urological Institute. Center for Advanced Research in Human Reproduction and Infertility. Cleveland. US
  • Agarwal, Ashok; Urological Institute. Center for Advanced Research in Human Reproduction and Infertility. Cleveland. US
  • Thomas Júnior, Anthony Joseph; Urological Institute. Center for Advanced Research in Human Reproduction and Infertility. Cleveland. US
Artigo em Inglês | LILACS | ID: lil-342122
ABSTRACT

PURPOSE:

Infertility is one of the less common presenting features associated with testicular tumors. We evaluated the histologic and biochemical findings, and pregnancy outcome in patients presenting with infertility who were found to have testicular tumors.

METHODS:

Seven patients with infertility were found to have testicular cancer over a 15-year period. All patients had a testicular ultrasound evaluation. The indications for the ultrasound were testicular pain in 2 patients, suspicious palpable mass in 4, and to rule out the presence of germ cell neoplasia in a patient with carcinoma in situ detected on a previous biopsy. Physical exam, histological findings, hormonal levels, tumor markers, and pregnancy outcome results were recorded from the patients medical charts.

RESULTS:

Two men had elevated serum follicle stimulant hormone and luteinizing hormone levels, 1 of them had an abnormally low serum testosterone level. Tumor markers were normal in all patients. In 4 patients the tumor was on the right side and in 3 on the left. The histological diagnoses were seminoma (n = 5), Leydig cell tumor (n = 1), and carcinoma in situ (n = 1). Of the 7 patients, 5 underwent adjuvant radiation therapy. Two patients had sperm cryopreserved. Follow up on fertility status was available in 6 cases. One patient has established a pregnancy and 5 did not achieve a pregnancy after treatment for their cancer.

CONCLUSIONS:

Most of the men who have testicular cancer and male infertility have a seminona. Therefore, men who present with infertility should be thoroughly investigated to rule out such serious, concomitant diseases along with their infertility
Assuntos
Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Neoplasias Testiculares / Infertilidade Masculina Tipo de estudo: Estudo diagnóstico Limite: Adulto / Feminino / Humanos / Masculino / Gravidez Idioma: Inglês Revista: Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo Assunto da revista: Medicina Ano de publicação: 2003 Tipo de documento: Artigo País de afiliação: Estados Unidos Instituição/País de afiliação: Urological Institute/US

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Neoplasias Testiculares / Infertilidade Masculina Tipo de estudo: Estudo diagnóstico Limite: Adulto / Feminino / Humanos / Masculino / Gravidez Idioma: Inglês Revista: Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo Assunto da revista: Medicina Ano de publicação: 2003 Tipo de documento: Artigo País de afiliação: Estados Unidos Instituição/País de afiliação: Urological Institute/US