Field evaluation of the whole blood immunochromatographic test for rapid bancroftian filariasis diagnosis in the northeast of Brazil
Rev. Inst. Med. Trop. Säo Paulo
;
45(3): 125-129, May-Jun. 2003.
Artigo
em Inglês
| LILACS
| ID: lil-342163
RESUMO
This study evaluated the whole blood immunochromatographic card test (ICT card test) in a survey performed in Northeastern Brazil. 625 people were examined by the thick blood film (TBF) and ICT card test. Residents of a non-endemic area were also tested by the whole blood card test and Og4C3. The sensitivity of the ICT card test was 94.7 percent overall, but lower in females than males, based on the reasonable assumption that TBF is 100 percent specific. However, since TBF and other methods have unknown sensitivity, the true specificity of the card test is unknown. Nevertheless, it is possible to estimate upper and lower limits for the specificity, and relate it to the prevalence of the disease. In the endemic area, the possible range of the specificity was from 72.4 percent to 100 percent. 29.6 percent of the card tests performed in the non-endemic area exhibited faint lines that were interpreted as positives. Characteristics of the method including high sensitivity, promptness and simplicity justify its use for screening of filariasis. However, detailed information about the correct interpretation in case of extremely faint lines is essential. Further studies designed to consider problems arising from imperfect standards are necessary, as is a sounder diagnostic definition for the card test
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Kit de Reagentes para Diagnóstico
/
Wuchereria bancrofti
/
Filariose
/
Antígenos de Helmintos
Tipo de estudo:
Estudo diagnóstico
/
Guia de Prática Clínica
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
Limite:
Animais
/
Feminino
/
Humanos
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Rev. Inst. Med. Trop. Säo Paulo
Assunto da revista:
Medicina Tropical
Ano de publicação:
2003
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
/
Reino Unido
Instituição/País de afiliação:
Fundação Oswaldo Cruz/BR
/
London University/GB
/
Universidade Federal da Bahia/BR
/
Universidade Federal de Pernambuco/BR
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