Distribución de alelos de los genes DRD4 y DAT1 del sistema dopaminérgico en la población mixta de Santiago de Chile / Distribution of alleles of DRD4 and DAT1 genes of the dopaminergic system in the mixed chilean population
Rev. méd. Chile
; 131(2): 135-143, 2003. tab
Article
em Es
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| ID: lil-342234
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CL1.1
ABSTRACT
Genes for dopamine receptor DRD4 and dopamine transporter DAT1 are highly polymorphic. Two alleles of these genes, namely the DRD4.7 and the DAT1*9 are frequently associated to the attention deficit disorder with hyperactivity. In Europe, the allele for DRD4 receptor with four repetitions (DRD4.4) has the highest frequency, with a median of 69 percent, followed by DRD4.7, with a frequency of 15 percent. South American indigenous populations have higher frequencies for DRD4.7 (61 percent) than for DRD4.4 (29 percent). The ten repetition allele for DAT1 transporter has a high frequency among Europeans (72 percent) and Amerindians (100 percent). The allele DAT1*9 is the second most frequent allele. Aim:
To study the frequency of DRD4 and DAT1 alleles in a Chilean population sample. Material andmethods:
One hundred serum samples were obtained from blood donors in two public hospitals in Santiago. Polymorphic regions for DRD4 and DAT1 were amplified by polymerase chain reaction.Results:
The allele DRD4.4 had a frequency of 59 percent and DRD4.7 a frequency of 27 percent. The allele DAT1*10 had a frequency of 74 percent, followed by DAT 1*9, with a frequency of 23 percent.Discussion:
In a Chilean population sample, the frequency of DRD4 and DAT1 alleles was very similar to that of European populations
Texto completo:
1
Índice:
LILACS
Assunto principal:
Marcadores Genéticos
/
Receptores Dopaminérgicos
/
Transtornos Relacionados ao Uso de Substâncias
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
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Adult
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Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Chile
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
2003
Tipo de documento:
Article
/
Project document