The association of genetic markers and malaria infection in the Brazilian Western Amazonian region
Mem. Inst. Oswaldo Cruz
;
98(4): 455-460, June 2003. mapas, tab
Artigo
em Inglês
| LILACS
| ID: lil-344234
RESUMO
Almost all individuals (182) belonging to an Amazonian riverine population (Portuchuelo, RO, Brazil) were investigated for ascertaining data on epidemiological aspects of malaria. Thirteen genetic blood polymorphisms were investigated (ABO, MNSs, Rh, Kell, and Duffy systems, haptoglobins, hemoglobins, and the enzymes glucose-6-phosphate dehydrogenase, glyoxalase, phosphoglucomutase, carbonic anhydrase, red cell acid phosphatase, and esterase D). The results indicated that the Duffy system is associated with susceptibility to malaria, as observed in other endemic areas. Moreover, suggestions also arose indicating that the EsD and Rh loci may be significantly associated with resistance to malaria. If statistical type II errors and sample stratification could be ruled out, hypotheses on the existence of a causal mechanism or an unknown closely linked locus involved in susceptibility to malaria infection may explain the present findings
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Fenótipo
/
Plasmodium falciparum
/
Plasmodium vivax
/
Malária Vivax
/
Malária Falciparum
/
Eritrócitos
Tipo de estudo:
Fatores de risco
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2003
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Centro de Pesquisas em Doenças Tropicais/BR
/
Universidade de São Paulo/BR
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