Production of septal fibrosis of the liver by means of foreign protein injections into rats
Rev. Soc. Bras. Med. Trop
;
36(5): 577-580, set.-out. 2003. ilus, graf
Artigo
em Inglês
| LILACS
| ID: lil-348028
RESUMO
Similarities and differences in antigenic humoral responses and electrophoretic patterns between Capillaria hepatica and pig-serum were investigated as a contribution to the understanding of hepatic fibrosis induced by the parenteral administration of foreign proteins. Only two out of 10 rats receiving repeated intraperitoneal injections of an extract of Capillaria hepatica-infected mouse liver presented septal hepatic fibrosis (20 percent). Under the same experimental conditions, 4 out of 9 rats (44.4 percent) developed septal fibrosis following whole pig-serum administration. Injections of normal mouse liver extracts did not result in hepatic fibrosis. Since a 100 percent septal fibrosis rate is observed in experimentally Capillaria hepatica-infected rats, it appeared that Capillaria hepatica products continuously released from inside the liver creates a much more effective fibrosis inducing mechanism than the parenteral administration of such factors. Thus, repeated peritoneal administration of a foreign protein to rats would not reveal the full fibrogenic potential it may have under natural conditions
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Capillaria
/
Infecções por Enoplida
/
Cirrose Hepática Experimental
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
Medicina Tropical
Ano de publicação:
2003
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Fundaçäo Oswaldo Cruz/BR
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