A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation
Arq. neuropsiquiatr
;
61(3B): 738-745, Sept. 2003. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-348651
ABSTRACT
Oxidative stress causes metabolic and structural abnormalities during reperfusion. In an animal model of electrophysiological evaluation of cerebral ischemia-reperfusion, alpha-lipoic acid effect on the oxidative stress was studied by mean absolute amplitude of EEG spectra evaluation. The left carotideal infusion of 3.03 mM alpha-lipoic acid in Wistar rats after cerebral ischemia and reperfusion caused initial reduction and partial final recuperation of the various EEG spectral frequency mean absolute amplitudes (p<0.05). The left intracarotideal infusion of 6.06 mM alpha-lipoic acid significantly reverted the induced depression of mean absolute amplitude of theta and delta spectra. Nevertheless there was an increasing pattern of ischemia demonstrated by mean absolute amplitude depression of almost all EEG spectra with 60.6 mM alpha-lipoic acid infusion. These observations suggest that, depending on the administered concentration, alpha-lipoic acid may act in a dual way, protecting from ischemia at lower concentrations and worsening this process at higher doses
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Encéfalo
/
Isquemia Encefálica
/
Ácido Tióctico
/
Estresse Oxidativo
/
Eletroencefalografia
/
Antioxidantes
Limite:
Animais
Idioma:
Inglês
Revista:
Arq. neuropsiquiatr
Assunto da revista:
Neurologia
/
Psiquiatria
Ano de publicação:
2003
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Estadual do Ceará/BR
/
Universidade Federal do Ceará/BR
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