Age-related changes of the multidrug resistance P-glycoprotein function in normal human peripheral blood T lymphocytes
Braz. j. med. biol. res
;
36(12): 1653-1657, Dec. 2003. ilus
Artigo
em Inglês
| LILACS
| ID: lil-350469
RESUMO
The multidrug resistance P-glycoprotein is a transmembrane efflux pump expressed by lymphocytes and is involved in their cytolytic activity. In the present study, we investigated the age-related changes of P-glycoprotein function in normal peripheral blood lymphocytes. Blood samples from 90 normal volunteers (age range, 0 to 86 years) were analyzed. P-glycoprotein function was assessed by the flow cytometric rhodamine 123 assay. P-glycoprotein function was highest in cord blood and progressively declined with age in peripheral blood T CD4+ and CD8+ cells. In contrast, P-glycoprotein function did not vary with age in CD19+ B or CD16+CD56+ natural killer cells. These data suggest that the decline in P-glycoprotein function in T CD4+ and CD8+ lymphocytes as a function of age may contribute to the decrease in T cell cytolytic activity with aging.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Linfócitos T
/
Membro 1 da Subfamília B de Cassetes de Ligação de ATP
/
Resistência a Múltiplos Medicamentos
Limite:
Adolescente
/
Adulto
/
Aged80
/
Criança
/
Criança, pré-escolar
/
Humanos
/
Lactente
/
Recém-Nascido
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2003
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade de São Paulo/BR
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