Complete sequence of the genome of the human isolate of Andes virus CHI-7913: comparative sequence and protein structure analysis
Biol. Res
;
36(2): 201-210, July 2003. tab
Artigo
em Inglês
| LILACS
| ID: lil-351362
RESUMO
We report here the complete genomic sequence of the Chilean human isolate of Andes virus CHI-7913. The S, M, and L genome segment sequences of this isolate are 1,802, 3,641 and 6,466 bases in length, with an overall GC content of 38.7 percent. These genome segments code for a nucleocapsid protein of 428 amino acids, a glycoprotein precursor protein of 1,138 amino acids and a RNA-dependent RNA polymerase of 2,152 amino acids. In addition, the genome also has other ORFs coding for putative proteins of 34 to 103 amino acids. The encoded proteins have greater than 98 percent overall similarity with the proteins of Andes virus isolates AH-1 and Chile R123. Among other sequenced Hantavirus, CHI-7913 is more closely related to Sin Nombre virus, with an overall protein similarity of 92 percent. The characteristics of the encoded proteins of this isolate, such as hydrophobic domains, glycosylation sites, and conserved amino acid motifs shared with other Hantavirus and other members of the Bunyaviridae family, are identified and discussed
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Homologia de Sequência do Ácido Nucleico
/
Sequência de Aminoácidos
/
Genoma Viral
Tipo de estudo:
Estudo prognóstico
Limite:
Criança
/
Humanos
Idioma:
Inglês
Revista:
Biol. Res
Assunto da revista:
Biologia
Ano de publicação:
2003
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
Bios Chile IGSA/CL
/
Fundacion Ciencia para la Vida/CL
/
Instituto de Salud Publica de Chile/CL
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