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Ecstasy intoxication: the toxicological basis for treatment
Ferigolo, Maristela; Machado, Adriana G. da S; Oliveira, Niara B; Barros, Helena M. T.
  • Ferigolo, Maristela; Fundaçäo Faculdade Federal de Ciências Médicas de Porto Alegre. Division of Pharmacology. Psychoactive Substances Information Service. Porto Alegre. BR
  • Machado, Adriana G. da S; Fundaçäo Faculdade Federal de Ciências Médicas de Porto Alegre. Division of Pharmacology. Psychoactive Substances Information Service. Porto Alegre. BR
  • Oliveira, Niara B; Fundaçäo Faculdade Federal de Ciências Médicas de Porto Alegre. Division of Pharmacology. Psychoactive Substances Information Service. Porto Alegre. BR
  • Barros, Helena M. T; Fundaçäo Faculdade Federal de Ciências Médicas de Porto Alegre. Division of Pharmacology. Psychoactive Substances Information Service. Porto Alegre. BR
Artigo em Inglês | LILACS | ID: lil-354168
RESUMO
Youngsters are increasingly using 3,4 methylenedioxymethamphetamine, known as ecstasy, because it is wrongly believed that it does not induce harm. However, there are many reports of adverse effects, including acute intoxication, abuse potential, and possible neurotoxic effects. Therefore, health care providers need to promptly recognize the symptoms of systemic intoxication in order to initiate early treatment. The drug is used by the oral route for long hours during crowded dance parties. Acutely, ecstasy increases the release of serotonin and decreases its reuptake, leading to hypertension, hyperthermia, trismus, and vomiting. There is debate on whether recreational doses of ecstasy cause permanent damage to human serotonergic neurons. Ecstasy users showed a high risk of developing psychopathological disturbances. The prolonged use of ecstasy might induce dependence, characterized by tolerance and hangover. Acute ecstasy intoxication needs emergency-type treatment to avoid the dose-dependent increase in adverse reactions and in severity of complications. There are no specific antidotes to be used during acute intoxication. Supportive measures and medical treatment for each one of the complications should be implemented, keeping in mind that symptoms originate mainly from the central nervous system and the cardiovascular system
Assuntos
Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Alucinógenos Limite: Humanos Idioma: Inglês Revista: Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo Assunto da revista: Medicina Ano de publicação: 2003 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Fundaçäo Faculdade Federal de Ciências Médicas de Porto Alegre/BR

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Alucinógenos Limite: Humanos Idioma: Inglês Revista: Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo Assunto da revista: Medicina Ano de publicação: 2003 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Fundaçäo Faculdade Federal de Ciências Médicas de Porto Alegre/BR