Progress towards meningitis prevention in the conjugate vaccines era
Braz. j. infect. dis
;
7(5): 315-324, Oct. 2003. mapas, tab
Artigo
em Inglês
| LILACS
| ID: lil-354281
ABSTRACT
Acute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect) and of their carriage status (indirect effect). We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the potential of pneumococcal and meningococcal conjugate vaccines for the reduction of meningitis worldwide. We also address constraints for the development and delivery of these vaccines and review new candidate state-of-the-art vaccines. The greatest challenge, undoubtedly, is to implement these vaccines worldwide, especially in the developing regions.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Vacinas Bacterianas
/
Meningites Bacterianas
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Criança
/
Humanos
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2003
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
Federal University of Goiás/BR
/
Federal University of São Paulo/BR
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