Efecto de la administración oral de inulina sobre el perfil de lípidos y la sensibilidad a la insulina en individuos con obesidad y dislipidemia / Effect of oral inulin administration on lipid profile and insulin sensitivity in subjects with obesity and dyslipidemia
Rev. méd. Chile
;
131(6): 597-604, jun. 2003.
Artigo
em Espanhol
| LILACS
| ID: lil-356097
ABSTRACT
BACKGROUND:
Inulin is a non absorbable polysaccharide with prebiotic effects, whose influence on blood lipids or insulin sensitivity is not well knownAIM:
To assess the effect of oral administration of inulin on lipid profile and insulin sensitivity in dyslipidemic obese subjects. MATERIAL ANDMETHODS:
A clinical trial, double blind, randomized with placebo was carried out in 12 obese, hypertrygliceridemic and hypercholesterolemic subjects between 19 and 32 years old. The subjects were randomized to receive 7 g/day of inulin or placebo in the morning, during 4 weeks. Biochemical and metabolic profiles and euglycemic-hyperinsulinemic clamp technique for assessing insulin sensitivity, before and after pharmacological intervention were performed.RESULTS:
After inulin administration, there was a significant reduction of total cholesterol (248.7 +/- 30.5 and 194.3 +/- 39.8 mg/dL; p = 0.028), low density lipoprotein (LDL), cholesterol (136.0 +/- 27.8 and 113.0 +/- 36.2 mg/dL; p = 0.028), very low density lipoproteins (VLDL) (45.9 +/- 18.5 and 31.6 +/- 7.2 mg/dL; p = 0.046) and trygliceride concentrations (235.5 +/- 85.9 and 171.1 +/- 37.9 mg/dL; p = 0.046). No effect of inulin on insulin sensitivity was observed.CONCLUSIONS:
The oral inulin administration reduced total cholesterol, LDL cholesterol, VLDL and trygliceride levels in dyslipidemic and obese subjects, without modifications in the insulin sensitivity.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Resistência à Insulina
/
Hiperlipidemias
/
Inulina
/
Lipídeos
/
Obesidade
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo diagnóstico
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2003
Tipo de documento:
Artigo
País de afiliação:
México
Instituição/País de afiliação:
Instituto Mexicano del Seguro Social/MX
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