Predictive value of PSA velocity over early clinical and pathological parameters in patients with localized prostate cancer who undergo radical retropubic prostatectomy
Int. braz. j. urol
;
30(1): 12-17, Jan.-Feb. 2004. tab
Artigo
em Inglês
| LILACS
| ID: lil-359778
RESUMO
OBJECTIVES:
To analyze the behavior of the prostate specific antigen velocity (PSAV) in localized prostate adenocarcinoma. MATERIALS ANDMETHODS:
We conducted a retrospective study of 500 men who had localized prostate adenocarcinoma, who underwent radical retropubic prostatectomy between January 1986 and December 1999. The PSAV was calculated for each patient and subsequently, the values were correlated with 5 groups age, initial PSA value, clinical stage, tumor volume and Gleason score.RESULTS:
The behavior of PSAV presented statistic significance with an increment between 1.3 ng/mL and 9.6 ng/mL, ranging from 38.6 percent and 59.8 percent when compared with the initial PSA value (p < 0.0001), clinical stage (p = 0.0002), tumor volume (p < 0.0001) and Gleason score (p = 0.0009).CONCLUSION:
PSAV up to 2.5 ng/mL/year is associated with factors of good prognosis, such as initial PSA below 10 mg/mL, clinical stage T1, tumor volume below 20 percent and Gleason score lower than 7.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Prostatectomia
/
Neoplasias da Próstata
/
Adenocarcinoma
/
Antígeno Prostático Específico
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Idoso
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Int. braz. j. urol
Assunto da revista:
Urologia
Ano de publicação:
2004
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Federal University of São Paulo/BR
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