CCR5D32 mutation in three Brazilian populations of predominantly Sub-Saharan African ancestry
Genet. mol. biol
;
27(3): 321-325, Sept. 2004. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-366173
RESUMO
This study reports the frequencies of the CCR5D32 mutation of the beta-chemokine 5 gene and discusses the possible effects of past and recent gene flow in three quilombo remnants (Brazilians communities with anthropological African ancestry whose ancestors were escaped slaves): Rio das Rãs, Mocambo, and São Gonçalo in the northeastern region of Brazil. The CCR5D32 allele frequency of the Mocambo population was significantly higher (5.6 percent) than that found in the Rio das Rãs (1 percent) and São Gonçalo (0.9 percent) populations. These differences may reflect different proportions of parental populations in the founders individuals, a founder-effect and/or different histories of inter-ethnic contact. The frequency of the CCR5D32 allele in the Mocambo sample is similar to that found in those urban Brazilian populations which have a large amount of European genetic input, indicating a European contribution to the gene pool of this population and suggesting that, perhaps since its foundation, Mocambo has had a high level of admixture or experienced a founder-effect.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Polimorfismo Genético
/
Etnicidade
/
Receptores CCR5
Limite:
Humanos
País/Região como assunto:
África
/
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Genet. mol. biol
Assunto da revista:
Genética
Ano de publicação:
2004
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de Pernambuco/BR
/
Universidade de Brasília/BR
/
Universidade de São Paulo/BR
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