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Efficacy and safety of Efavirenz in HIV patients on Rifampin for tuberculosis
Pedral-Sampaio, Diana B; Alves, Carmosina R; M. Netto, Eduardo; Brites, Carlos; Oliveira, Adriano S; Badaro, Roberto.
Afiliação
  • Pedral-Sampaio, Diana B; Federal University of Bahia. BR
  • Alves, Carmosina R; CREAIDS. Salvador. BR
  • M. Netto, Eduardo; Federal University of Bahia. BR
  • Brites, Carlos; Federal University of Bahia. BR
  • Oliveira, Adriano S; CREAIDS. Salvador. BR
  • Badaro, Roberto; Federal University of Bahia. BR
Braz. j. infect. dis ; 8(3): 211-216, Jun. 2004. tab, graf
Article em En | LILACS | ID: lil-384159
Biblioteca responsável: BR1.1
ABSTRACT
Forty-nine AIDS patients, most of who were antiretroviral therapy (ARV) naïve, with active tuberculosis, were treated with Rifampin 600mg, Isoniazid 400mg and Pirazinamide 2g daily. They also received ARV, consisting of Efavirenz (600mg/day) plus 2 NRTIs. All patients were prospectively followed for at least 24 months. Baselines were male/female ratio 21, mean age 34.7 ± 9.4 yrs; weight 51 ± 9.0 kg, viral load 5.6 ± 0.6 logs, CD4 cell count 101 ± 128 cells/ mm . Follow up mean values of data logs of VL and CD4+ cell /mm counts were VL 1.7 and CD4+ 265; VL 1.3 and CD4+ 251; VL 1.4 and CD4+ 326 at 6, 12 and 24 months, respectively. Weight gain changes were 5 ± 9.9 ± 12 and 21 ± 16 kg respectively at 6, 12 and 24 months. A non-concomitant ARV regimen was introduced at least three weeks after TB treatment initiation. Severe adverse reactions included rash (two), toxic hepatitis (six), Immune Reconstitution Syndrome (seven), and four deaths. We conclude that Efavirenz at a daily dose of 600 mg is sufficient and safe to treat HIV/TB patients using a Rifampin containing regimen.
Assuntos
Texto completo: 1 Índice: LILACS Assunto principal: Rifampina / Tuberculose Pulmonar / Infecções por HIV / Fármacos Anti-HIV / Antibióticos Antituberculose Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2004 Tipo de documento: Article
Texto completo: 1 Índice: LILACS Assunto principal: Rifampina / Tuberculose Pulmonar / Infecções por HIV / Fármacos Anti-HIV / Antibióticos Antituberculose Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2004 Tipo de documento: Article