Interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: un diseño case-only / Gene-gene and gene-environment interactions as modifier factors of prostatic cancer risk: a case-only design study
Rev. méd. Chile
;
132(8): 961-970, ago. 2004. tab
Artigo
em Espanhol
| LILACS
| ID: lil-384192
ABSTRACT
Background:
The role of susceptibility low penetrance genes and environmental factors in the etiology of prostate cancer (PCa) is unclear, but may involve in some cases multiple alleles at multiple loci.Aim:
To evaluate the association of gene-gene and gene-environment interactions with PCa. Patients andmethods:
One hundred three subjects with biopsy proven PCa were studied, using a case-only design. All were interrogated about smoking habits. Polymorphisms for Glutathione-S-transferase (GST) and Cytochrome P4501A1 (CYP1A1), were measured in DNA extracted from peripheral Iymphocytes, using a restriction fragment length polymorphism analysis.Results:
Our findings suggest that gene-gene interactions between GSTT1 and CYP1A1 high risk genotypes were positive modifiers and had a high predictive value for the presence of PCa, compared with non-susceptibility genotypes. The interaction between susceptibility genotypes and smoking did not modify the risk for PCa.Conclusions:
Gene-gene interactions may play a role modulating the susceptibility to PCa in a proportion of affected individuals (Rev Méd Chile 2004; 132 961-66).
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Polimorfismo Genético
/
Predisposição Genética para Doença
/
Meio Ambiente
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Idoso
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2004
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Chile
Instituição/País de afiliação:
Corporación Nacional del Cáncer/CL
/
Universidad de Chile/CL
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