Síndrome de mononucleosis infecciosa en pacientes adolescentes y adultos / Infectious mononucleosis syndrome in adolescents and adult patients
Rev. chil. infectol
;
20(4): 234-242, 2003. tab
Artigo
em Espanhol
| LILACS
| ID: lil-387921
RESUMEN
Infectious mononucleosis syndrome, characterized in typical cases by fever, sore throat, tonsillar exudates, cervical adenopathies and atypical lymphocytosis is associated in most cases to Epstein-Barr virus (EBV) infection. Other potential causes for this syndrome are acute cytomegalovirus (CMV), Human Immunodeficiency Virus, Toxoplasma gondii or Human Herpes virus 6 infection. These alternative etiologies evolve with a modified clinical picture that includes sometimes leukopenia or rash. Diagnosis of EBV is easily accomplished by atypical lymphocytosis (> 10 por ciento), positive heterophil antibodies and IgM antibodies directed against the EB viral capsid antigen (VCA). The latter is needed for cases without positive heterophil antibodies. Acute CMV infection is the second most important cause and can be diagnosed by CMV antigen detection, PCR or shell vial culture of blood samples, although experience with these tests among immunocompetent patients in primary care settings is sparse. Acute primary HIV infection is an important cause for this syndrome and should not be neglected when other causes are discarded. Third or fourth generation HIV ELISA tests, p24 antigen or HIV-PCR detection in blood samples allow recognition of this agent from the second or third week of inoculation. T. gondii and human herpes virus 6 infection can be diagnosed by serological methods. Evolution of EBV or CMV infection is favorable with infrequent complications.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Mononucleose Infecciosa
Tipo de estudo:
Estudo diagnóstico
Limite:
Adolescente
/
Adulto
/
Humanos
Idioma:
Espanhol
Revista:
Rev. chil. infectol
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2003
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
Hospital Clínico Universidad de Chile/CL
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