Detection of mutator phenotype in Brazilian patients with acute and chronic myeloid leukemia
Genet. mol. biol
;
27(4): 483-488, Dec. 2004. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-391217
RESUMO
The multisteps of tumorigenesis involve the classic chromosomal instability and the mutator phenotype pathways featured by a predisposition to acquire mutations in tumor suppressor genes and oncogenes. Expansion and contraction of microsatellite sequences due to a deficient mismatch repair system are a marker of the mutator phenotype. Controversial results regarding the extent of microsatellite instability (MSI) have been reported in the development and progression of myeloid malignancies. Here, we investigated MSI and loss of heterozygosity (LOH) frequencies at the microsatellite loci BAT-26, D7S486, D8S135, ANK1, IFNA, TP53 and bcr of 19 Brazilian patients with acute (AML) and chronic myeloid leukemia (CML). One AML patient and one CML patient were categorized as having a high degree of microsatellite instability (MSI-H), corresponding to 10.5 percent (2/19) of all patients. LOH at loci BAT-26 and TP53 was present in 30 percent of the patients with AML alone. Despite the small sample size, our results suggest that the mutator phenotype, as verified by MSI frequency, could play a role in the leukemogenesis of a small subset of patients with myeloid leukemia.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Reação em Cadeia da Polimerase
/
Mutação
Tipo de estudo:
Estudo diagnóstico
Limite:
Adulto
/
Humanos
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Genet. mol. biol
Assunto da revista:
Genética
Ano de publicação:
2004
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Católica de Goiás/BR
/
Universidade Federal de Goiás/BR
Similares
MEDLINE
...
LILACS
LIS