Naturally acquired immunity to Haemophilus influenzae type B in healthy Cuban children
Mem. Inst. Oswaldo Cruz
;
99(7): 687-689, Nov. 2004. tab
Artigo
em Inglês
| LILACS
| ID: lil-391595
RESUMO
We have evaluated the prevalence of antibody to immunogenicity of Haemophilus influenzae type b (Hib) in a group of 4 to 5 years old healthy children, who were too old to be included in the first vaccinated cohort when Hib vaccination begun in Cuba in 1999. Serum capsular polysaccharide specific IgG antibody concentrations were measured in 974 healthy children, between February and May 2002. The prevalence of Hib nasopharyngeal carriage was also estimated. The majority of children (99.7 percent) had more than 1 µg/ml of antibody. The preliminary report of the nasopharyngeal cultures was positive for H. influenzae in 16 children, but in only one was confirmed as Hib after serotyping (0.1 percent Hib nasopharyngeal carrier). These results provide evidence that in Cuba the natural active immunity to Hib can be acquired at an early age.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Polissacarídeos Bacterianos
/
Imunoglobulina G
/
Haemophilus influenzae tipo b
/
Imunidade Inata
/
Anticorpos Antibacterianos
Tipo de estudo:
Estudo de prevalência
/
Fatores de risco
Limite:
Criança, pré-escolar
/
Humanos
País/Região como assunto:
Caribe
/
Cuba
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2004
Tipo de documento:
Artigo
País de afiliação:
Cuba
Instituição/País de afiliação:
Instituto de Medicina Tropical Pedro Kourí/CU
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