Relación de la genotipificación de Helicobacter pylori con la forma e intensidad de la gastritis en población adulta portadora de patología gástrica benigna / Association between helicobacter pylori genotype and the severity of gastritis in infected adults
Rev. méd. Chile
;
132(11): 1345-1354, nov. 2004. ilus, tab, graf
Artigo
em Espanhol
| LILACS
| ID: lil-391838
ABSTRACT
Background:
The damaging capacity of Helicobacter pylori is variable and depends, in part, on its genetic polymorphism.Aim:
To study H pylori genes vacA, cagA and iceA and the relationship of these genotypes with the features of acute damage in chronic gastritis. Material andmethods:
Gastric endoscopic biopsies were obtained in 75 adults for pathological study and genetic typification of H pylori by specific PCR.Results:
In only 64 cases, complete information was available. In 53 of these, there was H pylori infection demonstrated by PCR. Twenty one percent had infection by two or more H pylori strains, vacA gene had genotypes s2/m2, s1/m1 and s1/m2 in 36, 25 and 8% of cases respectively, cagA gene was present in 49% of infected patients. iceA gene had genotypes iceA 1 ad iceA 2 in 15 and 60% of patients respectively. The presence of cagA or alleles s1/m1 and s1/m2 of vacA gene was directly correlated with polymorphonuclear infiltration and the severity of epithelial damage. The genotype s2/m2 of vacA gene was significantly associated with a milder or absent mucosal damage. No association was found between iceA alleles and the pathological features of gastritis.Conclusions:
Alleles of vacA and cagA genes of H pilory are associated with the severity of gastric mucosal damage.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Proteínas de Bactérias
/
Fatores de Transcrição
/
Helicobacter pylori
/
Infecções por Helicobacter
/
Gastrite
/
Genes Bacterianos
/
Antígenos de Bactérias
Tipo de estudo:
Fatores de risco
Limite:
Animais
/
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2004
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Chile
Instituição/País de afiliação:
Universidad de La Frontera/CL
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