Candidiasis esofágica en pacientes inmunocompetentes: estudio clínico e inmunológico / Clinical and immunological study of 10 immunocompetent patients with esophageal candidiasis
Rev. méd. Chile
;
132(11): 1389-1394, nov. 2004. ilus, tab
Artigo
em Espanhol
| LILACS
| ID: lil-391844
ABSTRACT
Background:
Esophageal candidiasis is associated with conditions that cause an immune depression. It is a defining disease for AIDS, is observed in poorly controlled diabetics, in patients with renal or hepatic failure, in patients with cancer and in subjects using medications causing immunosuppression or broad spectrum antimicrobials.Aim:
To report the features of 10 immunocompetent patients with esophageal candidiasis. Patients andmethods:
Six males and four females aged between 48 and 82 years, without conditions associated with immunosuppression, in whom an esophageal candidiasis was found on an upper gastrointestinal endoscopy. Delayed skin hypersensitivity to eight antigens, Iymphocyte subpopulations, yeast phagocytosis and neutrophil chemotaxis were measured.Results:
Six patients had a low CD4 Iymphocyte count and seven had a low CD8 count. Seven patients were anergic on skin hypersensitivity challenge. Yeast phagocytosis was abnormal in one patient and neutrophil chemotaxis was abnormal in two. Humoral immunity was normal in all subjects. All patients were treated with oral fluconazole in doses of 150 mg/day for 14 days, with complete resolution of candidiasis in all.Conclusions:
Patients with esophageal candidiasis, have frequent alterations of cellular immunity, that must be diagnosed and treated.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Candidíase
/
Doenças do Esôfago
/
Imunocompetência
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2004
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
Universidad de Chile/CL
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