The importance of accurate anatomic assessment for the volumetric analysis of the amygdala
Braz. j. med. biol. res
; 38(3): 409-418, mar. 2005. ilus, tab
Article
em En
| LILACS
| ID: lil-394793
Biblioteca responsável:
BR1.1
RESUMO
There is a wide range of values reported in volumetric studies of the amygdala. The use of single plane thick magnetic resonance imaging (MRI) may prevent the correct visualization of anatomic landmarks and yield imprecise results. To assess whether there is a difference between volumetric analysis of the amygdala performed with single plane MRI 3-mm slices and with multiplanar analysis of MRI 1-mm slices, we studied healthy subjects and patients with temporal lobe epilepsy. We performed manual delineation of the amygdala on T1-weighted inversion recovery, 3-mm coronal slices and manual delineation of the amygdala on three-dimensional volumetric T1-weighted images with 1-mm slice thickness. The data were compared using a dependent t-test. There was a significant difference between the volumes obtained by the coronal plane-based measurements and the volumes obtained by three-dimensional analysis (P < 0.001). An incorrect estimate of the amygdala volume may preclude a correct analysis of the biological effects of alterations in amygdala volume. Three-dimensional analysis is preferred because it is based on more extensive anatomical assessment and the results are similar to those obtained in post-mortem studies.
Texto completo:
1
Índice:
LILACS
Assunto principal:
Imageamento por Ressonância Magnética
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Imageamento Tridimensional
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Epilepsia do Lobo Temporal
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Tonsila do Cerebelo
Tipo de estudo:
Observational_studies
Limite:
Female
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Humans
/
Male
Idioma:
En
Revista:
Braz. j. med. biol. res
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
2005
Tipo de documento:
Article
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Project document