Susceptibilidad a antimicrobianos de Streptococcus pneumoniae en poblacion infantil y adulta de Santiago: Periodo 1997-2003 / Antimicrobial susceptibility of Streptococcus pneumoniae in pediatric and adult population from Santiago, 1997-2003
Rev. méd. Chile
;
133(1): 42-49, ene. 2005. tab, graf
Artigo
em Espanhol
| LILACS
| ID: lil-398015
RESUMEN
Background:
In Chile, the emergence of drug-resistant strains of Streptococcus pneumoniae has complicated treatment decisions and may lead to treatment failures.Aim:
to examine antimicrobial resistance trends among pneumococcal isolates from the Catholic University Hospital between 1997 and 2003. Material andmethods:
During a seven-year period, we examined 901 strains of S. pneumoniae isolated from sterile and non-sterile samples from adult and pediatric population.Results:
Overall, 20percent of isolates showed intermediate resistance to penicillin (MIC 0.12-1 µg/ml) y 10.8percent high level of resistance to penicillin (MIC 2 µg/ml). Pneumococcal resistance to penicillin did not change significantly during the study period, but it was more common in pediatric patients and isolates from non-sterile samples. No isolate had a MIC 8 µg/ml for penicillin. Twenty one percent of pneumococcal strains were resistant to erythromycin, 41.6percent to trimethoprim-sulfamethoxazole and 3.6percent to chloramphenicol. Macrolides resistance tended to increase between 1997 and 2003. Fourteen percent of strains showed intermediate resistance (MIC 1 µg/ml) and 2.5percent, a high level of resistance to cefotaxime (MIC 2 µg/ml). No isolate had a CIM 4 µg/ml for cefotaxime. Among those isolates with intermediate or high level of resistance to penicillin, there were significantly more isolates highly resistant to erythromycin, trimethoprim-sulfamethoxazole and cefotaxime.Conclusions:
Multidrug-resistant pneumococci are common and are increasing in our country, particularly in pediatric population, probably associated to indiscriminate ambulatory prescription of antimicrobials.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Streptococcus pneumoniae
/
Farmacorresistência Bacteriana
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Chile
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
Pontificia Universidad Católica de Chile/CL
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