A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat
Braz. j. med. biol. res
;
38(4): 615-619, Apr. 2005. ilus, graf
Artigo
em Inglês
| LILACS
| ID: lil-398183
ABSTRACT
Nine lead electrocardiograms of non-infarcted (N = 61) and infarcted (N = 71) female Wistar rats (200-250 g) were analyzed in order to distinguish left ventricle myocardial infarction (MI) larger than 40 percent (LMI) from MI smaller than 40 percent (SMI). MI larger than 40 percent clearly caused a deviation of AQRS and AT from normal values of 270-360 degrees to 90-270 degrees. Infarcted rats showed Q wave in D1 larger than 1 mm with 94 percent sensitivity and 100 percent specificity. The sum of QRS positivity in V1, V2 and V6 lower than 10 mm identified MI with 82 percent sensitivity and 100 percent specificity. The data showed that MI can be easily and reliably diagnosed by electrocardiogram in the rat. However, contradicting what is frequently believed, when specificity and sensitivity were analyzed focusing on MI size, none of these current electrocardiographic indices of MI size adequately discriminates LMI from SMI.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Eletrocardiografia
/
Infarto do Miocárdio
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2005
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de São Paulo/BR
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