Obesity influences propranolol pharmacokinetics in patients undergoing coronary artery bypass grafting employing cardiopulmonary bypass
RBCF, Rev. bras. ciênc. farm. (Impr.)
;
39(4): 409-414, out.-dez. 2003. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-399451
ABSTRACT
Propranolol plasma levels and kinetic disposition may be altered by hypoyhermic cardiopulmonary bypass (CPB-H). We investigated the potential influence of obesity on propranolol pharmacokinetics in patients undergoing coronary artery bypass grafting employing CPB-H. Fifteen patients, receiving propranolol perorally pre-(10-40 mg, 2-3 times a day) and post-operatively (10 mg, once a day) were distributed in two groups, based on body mass index (BMI), in obese (n=9, BMI mean 29,4 kg/m²) and non-obese (n=6 BMI mean 24.8 kg/m²). A serial of blood samples was collected at the pre- and post-operative periods at time dosing interval (`tau´) propranolol plasma levels were measured one day before and after surgery using a high performance liquid chromatographic procedure described previously...
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Propranolol
/
Circulação Extracorpórea
/
Revascularização Miocárdica
/
Obesidade
Limite:
Humanos
Idioma:
Inglês
Revista:
RBCF, Rev. bras. ciênc. farm. (Impr.)
Assunto da revista:
Bioquímica
/
Farmácia
/
Farmacologia
Ano de publicação:
2003
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade de São Paulo/BR
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