Regulation of endothelial derived nitric oxide in health and disease
Mem. Inst. Oswaldo Cruz
;
100(supl.1): 15-18, Mar. 2005.
Artigo
em Inglês
| LILACS
| ID: lil-402170
ABSTRACT
Endothelial nitric oxide synthase (eNOS) is the primary physiological source of nitric oxide (NO) that regulates cardiovascular homeostasis. Historically eNOS has been thought to be a constitutively expressed enzyme regulated by calcium and calmodulin. However, in the last five years it is clear that eNOS activity and NO release can be regulated by post-translational control mechanisms (fatty acid modification and phosphorylation) and protein-protein interactions (with caveolin-1 and heat shock protein 90) that direct impinge upon the duration and magnitude of NO release. This review will summarize this information and apply the post-translational control mechanisms to disease states.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Arteriosclerose
/
Endotélio Vascular
/
Diabetes Mellitus
/
Óxido Nítrico Sintase Tipo III
/
Cirrose Hepática
/
Óxido Nítrico
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Estados Unidos
Instituição/País de afiliação:
Yale University/US
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