Nitric oxide synthase activity and endogenous inhibitors in rats recovered from allergic encephalomyelitis
Mem. Inst. Oswaldo Cruz
;
100(supl.1): 25-27, Mar. 2005. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-402172
ABSTRACT
We have previously reported that in comparison with normal rats, the presence of experimental allergic encephalomyelitis (EAE) leads to decreased endogenous inhibitory activity (EIA) of Ca2+-dependent nitric oxide synthase (NOS) in both brain and serum, and increased expression of protein 3-nitrotyrosine (NT) in brain. In this work we show that animals recovered from the clinical signs of EAE are not different from controls in terms of either brain NOS activity, EIA of NOS, or NT expression. These results suggest that parallel to the reversal of the disease symptoms, a normalization of the production of nitric oxide and related species occurs.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Encéfalo
/
Encefalomielite Autoimune Experimental
/
Óxido Nítrico Sintase Tipo III
/
Óxido Nítrico
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade de São Paulo/BR
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