Lipoxin agonists: turn right! to path of resolving neutrophil
Mem. Inst. Oswaldo Cruz
;
100(supl.1): 55-57, Mar. 2005. ilus
Artigo
em Inglês
| LILACS
| ID: lil-402176
ABSTRACT
An impressive array of cellular and molecular adaptive responses achieves homeostasis. The inflammatory reaction is an adaptive response triggered by an insult to culminate into the overt cardinal signs of inflammation, eventually leading to resolution and returning the organism back to its original centered state. This article focuses on some aspects of the lipoxin A4 signaling pathway during the resolution phase, to better understand molecular mechanisms by which a neutrophil directs an inflammatory reaction to switch off and resume homeostasis. Defining the resolution state of a neutrophil at the molecular level will aid in treatments of diseases that are associated with an exaggerated and uncontrolled inflammation.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Anti-Inflamatórios não Esteroides
/
Mediadores da Inflamação
/
Lipoxinas
/
Homeostase
/
Neutrófilos
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Estados Unidos
Instituição/País de afiliação:
Harvard Medical School/US
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