CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
Mem. Inst. Oswaldo Cruz
; 100(supl.1): 93-96, Mar. 2005.
Article
em En
| LILACS
| ID: lil-402181
Biblioteca responsável:
BR1.1
RESUMO
The comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control. The augmented expression of CCL5/RANTES and CCL3/MIP-1alpha, and their receptor CCR5, in the heart of T. cruzi-infected mice suggests a role for CC-chemokines and their receptors in the pathogenesis of T. cruzi-elicited myocarditis. Herein, we discuss our recent results using a CC-chemokine receptor inhibitor (Met-RANTES), showing the participation of CC-chemokines in T. cruzi infection and unraveling CC-chemokine receptors as an attractive therapeutic target for further evaluation in Chagas disease.
Texto completo:
1
Índice:
LILACS
Assunto principal:
Trypanosoma cruzi
/
Cardiomiopatia Chagásica
/
Receptores de Quimiocinas
/
Quimiocinas CC
/
Miocardite
Limite:
Animals
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2005
Tipo de documento:
Article