Beyond sepsis pathophysiology with cytokines: what is their value as biomarkers for disease severity?
Mem. Inst. Oswaldo Cruz
;
100(supl.1): 217-221, Mar. 2005.
Artigo
em Inglês
| LILACS
| ID: lil-402203
RESUMO
Sepsis is a major challenge in medicine. It is a common and frequently fatal infectious condition. The incidence continues to increase, with unacceptably high mortality rates, despite the use of specific antibiotics, aggressive operative intervention, nutritional support, and anti-inflammatory therapies. Typically, septic patients exhibit a high degree of heterogeneity due to variables such as age, weight, gender, the presence of secondary disease, the state of the immune system, and the severity of the infection. We are at urgent need for biomarkers and reliable measurements that can be applied to risk stratification of septic patients and that would easily identify those patients at the highest risk of a poor outcome. Such markers would be of fundamental importance to decision making for early intervention therapy or for the design of septic clinical trials. In the present work, we will review current biomarkers for sepsis severity and especially the use of cytokines as biomarkers with important pathophysiological role.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Índice de Gravidade de Doença
/
Citocinas
/
Sepse
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Instituto Oswaldo Cruz/BR
/
Universidade Federal do Rio de Janeiro/BR
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