Resistencia primaria a terapia antirretroviral en pacientes con infección por VIH/SIDA en Chile / Primary resistance to antiretroviral therapy in patients with HIV/AIDS in Chile
Rev. méd. Chile
;
133(3): 295-301, mar. 2005. ilus, tab
Artigo
em Espanhol
| LILACS
| ID: lil-404885
ABSTRACT
Background:
Resistance to antiretroviral therapy is a determining factor for therapeutic failure in HIV/AIDS. The prevalence of primary resistance (i.e. in those patients that have not received treatment) varies in different parts of the world.Aim:
To study the prevalence of primary resistance to antiretroviral drugs in patients living in Northern Santiago. Patients andmethods:
Viral load, lymphocyte subpopulations by flow cytometry and genotypic resistance testing were assessed in blood samples from 60 HIV-1 infected patients (mean age 37 years, 54 male).Results:
Mean CD4 cell count and viral load was 200 cells/ml and 142,840 RNA copies/ml respectively. Ten mutations were identified V179D, L10I/V, M361, L63P, A71T/V, Y115F, V118I and K20R. None of these mutations is associated to a high degree of resistance to reverse transcriptase inhibitors, nucleoside analogs (NRTI), non nucleoside analogs (NNRTI) or viral protease inhibitors.Conclusions:
This is a first approach to study antiretroviral resistance in Chilean patients. This study must be amplified, since the prevalence of resistance may experience changes with time.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Infecções por HIV
/
HIV-1
/
Terapia Antirretroviral de Alta Atividade
Tipo de estudo:
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Chile
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
Hospital San José/CL
/
Universidad de Chile/CL
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