Efeitos da terapia de reposição hormonal associada ou não a atorvastatina sobre o perfil lipídico e reatividade vascular / Effects of hormonal replacement therapy alone or in association with atorvastatin on lipid profile and vascular reactivity

RESUMO

Selecionaram-se 94 mulheres após a menopausa, entre 50 e 65 anos, hipertensas e hipercolesterolêmicas. Totas receberam dieta (4 semanas), placebo (4 semanas) e terapia medicamentosa de forma randomizada e duplo-cega (12 semanas) 1)Estradiol=E; 2)E+nortisterona=P; 3)Atorvastatina=A; 4)E+A; 5)E+P+A. Todas as formas de tratamento reduziram significativamente o colesterol total e o LDL-c. Somente os grupos E e E+A elevaram o HDL-c. Somente os grupos A, E e E+A aumentaram significativamente a dilatação fluxo-mediada da artéria braquial em relação às medidas basais.Ninety four women were selected with special characteristics after menopause, between 50 and 65 years old, hypertensive and hypercholesterolemic. They followed diet (4 weeks), placebo (4 weeks) and drug therapy (12 weeks) 1)Estradiol=E; 2)E+nortisterona=P; 3)Atorvastatina=A; 4)E+A; 5)E+P+A. All treatment forms significantly reduced total cholesterol and LDL-c. Only the groups E and E+A presented an increase in HDL-c. In comparison with baseline measurements, only the groups A, E and E+A significantly increased flow-mediated vasodilatation of the brachial artery...