Regulation of pituitary hormones and cell proliferation by components of the extracellular matrix
Braz. j. med. biol. res
;
38(10): 1487-1494, Oct. 2005.
Artigo
em Inglês
| LILACS
| ID: lil-409270
RESUMO
The extracellular matrix is a three-dimensional network of proteins, glycosaminoglycans and other macromolecules. It has a structural support function as well as a role in cell adhesion, migration, proliferation, differentiation, and survival. The extracellular matrix conveys signals through membrane receptors called integrins and plays an important role in pituitary physiology and tumorigenesis. There is a differential expression of extracellular matrix components and integrins during the pituitary development in the embryo and during tumorigenesis in the adult. Different extracellular matrix components regulate adrenocorticotropin at the level of the proopiomelanocortin gene transcription. The extracellular matrix also controls the proliferation of adrenocorticotropin-secreting tumor cells. On the other hand, laminin regulates the production of prolactin. Laminin has a dynamic pattern of expression during prolactinoma development with lower levels in the early pituitary hyperplasia and a strong reduction in fully grown prolactinomas. Therefore, the expression of extracellular matrix components plays a role in pituitary tumorigenesis. On the other hand, the remodeling of the extracellular matrix affects pituitary cell proliferation. Matrix metalloproteinase activity is very high in all types of human pituitary adenomas. Matrix metalloproteinase secreted by pituitary cells can release growth factors from the extracellular matrix that, in turn, control pituitary cell proliferation and hormone secretion. In summary, the differential expression of extracellular matrix components, integrins and matrix metalloproteinase contributes to the control of pituitary hormone production and cell proliferation during tumorigenesis.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Hormônios Hipofisários
/
Neoplasias Hipofisárias
/
Adenoma
/
Transformação Celular Neoplásica
/
Proteínas da Matriz Extracelular
/
Proliferação de Células
Tipo de estudo:
Estudo de etiologia
Limite:
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2005
Tipo de documento:
Artigo
/
Congresso e conferência
País de afiliação:
Argentina
/
Alemanha
Instituição/País de afiliação:
Max Planck Institute of Psychiatry/DE
/
Universidad de Buenos Aires/AR
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