Splicing factors are differentially expressed in tumors
Genet. mol. res. (Online)
;
3(4): 512-520, 2004. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-410895
RESUMO
Although alternative splicing of many genes has been found associated with different stages of tumorigenesis and splicing variants have been characterized as tumor markers, it is still not known whether these examples are sporadic or whether there is a broader association between the two phenomena. In this report we evaluated, through a bioinformatics approach, the expression of splicing factors in both normal and tumor tissues. This was possible by integrating data produced by proteomics, serial analysis of gene expression (SAGE) and microarray experiments. We observed a significant shift in the expression of splicing factors in tumors in both SAGE and microarray data, resulting from a large amount of experiments. We discuss that this supports the notion of a broader association between alternative splicing and cell transformation, and that splicing factors may be involved in oncogenic pathways.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Regulação Neoplásica da Expressão Gênica
/
Processamento Alternativo
/
Neoplasias
Limite:
Humanos
Idioma:
Inglês
Revista:
Genet. mol. res. (Online)
Assunto da revista:
Biologia Molecular
/
Genética
Ano de publicação:
2004
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Estados Unidos
Instituição/País de afiliação:
John Hopkins Universit/US
/
Ludwig Institute for Cancer Research/BR
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