Evaluation of five screening tests licensed in Argentina for detection of hepatitis C virus antibodies
Mem. Inst. Oswaldo Cruz
;
100(3): 303-307, May 2005. tab
Artigo
em Inglês
| LILACS
| ID: lil-411029
ABSTRACT
This study was conducted to compare among the most recent generation of five screening tests licensed in Argentina, in order to evaluate which of the tests has the best sensitivity for detection of antibodies against hepatitis C virus (HCV). The tests analyzed were: Detect-HCV (3.0) Biochem ImmunoSystems, Canada; Hepatitis C EIA Wiener Lab., Argentina; Equipar HCV Ab, Italy; Murex HCV 4.0, UK and Serodia-HCV particles agglutination test, Japan. The results obtained showed high discrepancy between the different kits used and show that some of the tests assessed have a low sensitivity for anti-HCV detection in both chronic infections and early seroconversion, and indicate that among the commercially available kits in Argentina, Murex HCV 4.0 (UK) and Serodia-HCV particles agglutination test (Japan) have the best sensitivity for HCV screening. Although the sensitivity of the assays is the first parameter to be considered for blood screening, more studies should be carried out to assess the specificity of such assays.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Kit de Reagentes para Diagnóstico
/
Hepatite C
/
Hepacivirus
/
Anticorpos Anti-Hepatite C
Tipo de estudo:
Estudo diagnóstico
/
Estudos de avaliação
/
Estudo de rastreamento
Limite:
Humanos
País/Região como assunto:
América do Sul
/
Argentina
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Argentina
Instituição/País de afiliação:
1Facultad de Ciencias Medicas/AR
/
Facultad de Ciencias Medicas/AR
/
Universidad Católica de Córdoba/AR
/
Universidad Nacional de Córdoba/AR
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