Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans
Mem. Inst. Oswaldo Cruz
;
100(3): 325-330, May 2005. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-411033
ABSTRACT
Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were not observed, 75 and 100 æM benznidazole induced an increasing of mitotic recombination events in diploid strain. Results were related to the induction of chromosomal breaks by the antiparasitic drug.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Aspergillus nidulans
/
Diploide
/
Mutagênicos
/
Nitroimidazóis
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Estadual de Maringá/BR
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