Caveolae a new subcellular transport organelle
Bol. Asoc. Méd. P. R
;
90(1/3): 30-33, Jan.-Mar. 1998.
Artigo
em Inglês
| LILACS
| ID: lil-411408
RESUMO
Recent advances have allowed the identification and characterization of well defined vesicular subcellular organelles involved in multiple basic cellular physiological processes, with demonstrated clinical relevance. Among these, three particular subcellular organelles have received special attention based on their proven and postulated participation in the sorting and targeting of small-and large-molecular weight molecules during exocytosis and endocytosis, and in cell signaling and transduction events. These have characteristic proteinaceous coat structures that allows their classification accordingly, into what has been described as clathrin coated vesicles and COP-coated vesicles and caveolae. In this review article a brief description of clathrin-coated vesicles and COP-coated vesicles is presented. Caveolae (CAV), in turn, constitute a novel subcellular organelle that has received special attention based on its proven and postulated participation in transcytosis, potocytosis, and in cell signaling and transduction events. In this review of the literature a more extensive discussion is presented of CAV. In this context the article discusses the structural features of caveolae, its constituent protein caveolin(s), the functional aspects of this new organelle, and its postulated clinical relevance
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Índice:
LILACS (Américas)
Assunto principal:
Organelas
/
Membrana Celular
/
Caveolinas
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Bol. Asoc. Méd. P. R
Assunto da revista:
Medicina
Ano de publicação:
1998
Tipo de documento:
Artigo
País de afiliação:
Porto Rico
Instituição/País de afiliação:
Ponce School of Medicine/PR
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