Neuronal intestinal dysplasia: a role for surgery?
Bol. Asoc. Méd. P. R
;
87(3/4): 60-63, Mar.-Apr. 1995.
Artigo
em Inglês
| LILACS
| ID: lil-411571
RESUMO
Neuronal intestinal dysplasia (NID) is a poorly understood colonic motility disorder with characteristic histopathological findings and clinical presentation. It is often associated with Hirschsprung's disease (HD) and can constitute a cause of failure of clinical improvement after adequate resectional pull-through surgery. Other conditions associated with NID are Chronic Intestinal Pseudo-obstruction (CIPO), anorectal malformations and Multiple Endocrine Neoplasia (MEN) II syndrome patients. To increase the diagnostic yield of NID the pathologist should be aware and use histochemistry evaluation of the rectal biopsy specimen in patients with history of constipation or unexplained bouts of diarrhea. Adequate sampling of the temporary proximal colostomy done to HD patients should be examined for NID pathological changes. Treatment has centered around the clinical picture with most cases managed medically with prokinetic agents, colonic irrigations, and bowel cathartics until improvement and normalization of histology occur. There is evidence of progressive maturation of the enteric nervous system with time. Surgery is indicated for patients with severe clinical deterioration after failed medical management
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Índice:
LILACS (Américas)
Assunto principal:
Enteropatias
/
Doenças do Sistema Nervoso
Limite:
Criança
/
Criança, pré-escolar
/
Humanos
/
Lactente
/
Recém-Nascido
Idioma:
Inglês
Revista:
Bol. Asoc. Méd. P. R
Assunto da revista:
Medicina
Ano de publicação:
1995
Tipo de documento:
Artigo
País de afiliação:
Porto Rico
Instituição/País de afiliação:
University of Puerto Rico/PR
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