Assessment of the neutralizing potency of ovine antivenom in a swiss mice model of Bothrops jararaca envenoming
J. venom. anim. toxins incl. trop. dis
;
11(3): 336-349, jul.-set. 2005. graf
Artigo
em Inglês
| LILACS
| ID: lil-414928
ABSTRACT
Alternative sources of anti-ophidic serum are being investigated due to the secondary effects associated with types I and II hypersensitivity reactions. In the present study we raised and evaluated the protective effect of an ovine antibothropic serum in a Swiss mice envenoming model. Ovine antiserum was obtained by immunization with seven increasing doses of bothropic venom associated with adjuvants. The neutralizing ability was tested by the lethal activity (2 LD50) neutralization and serum and splenic venom levels after antivenom administration to experimentally envenomed mice. The antiserum effect on local edema was also tested by injection of venom/antivenom mixtures into the mice footpads. Ovine antiserum neutralized lethal activity and also significantly decreased serum and splenic venom levels. However, this antiserum was not able to mediate any protective effect on edema triggered by bothropic venom
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Ovinos
/
Antivenenos
/
Bothrops
/
Venenos de Crotalídeos
/
Camundongos
Limite:
Animais
Idioma:
Inglês
Revista:
J. venom. anim. toxins incl. trop. dis
Assunto da revista:
Toxicologia
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Sao Paulo State University/BR
/
University of Sao Paulo/BR
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