Avaliação das concentrações de citocinas e suas relações com o estado metabólico e nutricional na criança gravemente doente / Evaluation of serum concentration of cytokines and its correlation with the metabolic and nutritional status in critically ill children

RESUMO

As crianças gravemente doentes apresentam resposta inflamatória generalizada, com liberação de citocinas e quimiocinas. Apresentam catabolismo protéico que pode ser minimizado com nutrição precoce. As diferenças nas respostas inflamatória, metabólica e nutricional entre desnutridos e eutróficos são pouco conhecidas. Assim sendo, foram estudados 14 pacientes eutróficos e 15 desnutridos gravemente doentes, internados em unidade de terapia intensiva pediátrica e classificados com os escores TISS e PRISM / Critically ill children have sistemic inflammatory response and release cytokines. They have proteolysis that can be reduced with early nutrition. The differences in the inflammatory, metabolic and nutritional responses between malnourished and well nourished are unknown. Because this, 14 well nourished and 15 malnourished critically ill patients were admitted to the pediatric intensive care unit. TISS and PRISM scores were utilized. The complete evaluation had anthropometric data and laboratory measurements (prealbumin, C-reactive protein, tumor necrosis factor-, interleukin-6, 8 and 10) on the first, fifth and tenth days of the study. Malnourished children had increased levels of cytokines...