Measurement of IL-10 serum levels in balb/c mice treated with beta-1, 3 polyglucose or sulfadiazine and acutely infected by Toxoplasma gondii
J. venom. anim. toxins incl. trop. dis
;
11(4): 540-556, out.-dez. 2005. tab
Artigo
em Inglês
| LILACS
| ID: lil-417725
ABSTRACT
Acute infection by Toxoplasma gondii leads to suppression of cell-mediated immunity, facilitating chronic infection. One of the causes of immunosuppression is Interleukin-10 (IL-10) production. Glucan is used to stimulate phagocytosis. Our objective was to study IL-10 induction in male BALB/c mice with acute T. gondii BTU-2 strain infection, glucan immunostimulation, and sulfadiazine treatment. Animals were distributed into 7 groups G1 infected with T. gondii; G2 infected with T. gondii and treated with sulfadiazine; G3 infected with T. gondii and immunostimulated with glucan; G4 infected with T. gondii, immunostimulated with glucan, and treated with sulfadiazine; G5 imunostimulated with glucan; G6 treated with saline; and G7 treated with sulfadiazine. IL-10 levels were determined by ELISA; the highest levels were found in G2, G3 and G4, and the lowest in G1 (p<0.001). Groups G1 to G5 and G7 had substantially higher levels than G6 (p<0.001). In this study, the highest IL-10 levels were found in groups treated with glucan
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Ratos
/
Sulfadiazina
/
Toxoplasma
/
Toxoplasmose Animal
Limite:
Animais
Idioma:
Inglês
Revista:
J. venom. anim. toxins incl. trop. dis
Assunto da revista:
Toxicologia
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
São Paulo State University/BR
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