Evaluation of the natural killer cytotoxicity and the levels of cytokines in rats with type I diabetes mellitus
Mem. Inst. Oswaldo Cruz
;
100(8): 883-887, Dec. 2005. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-419955
RESUMO
Type I diabetes mellitus (insulin-dependent DM = IDDM) is a chronic disease characterized by specific destruction of pancreatic beta cells, resulting in an absolute lack of insulin. Immune mechanisms, genetic susceptibility, and environmental factors are all implicated in the pathogenesis of Type 1 diabetes. This study was aimed at determining the efficiency of cytokines, natural killer (NK) cells in the pathophysiology of IDDM. Therefore, we evaluated the plasma levels of cytokines by specific enzyme-linked immunosorbent assay (ELISA) and the cytotoxicity activity of NK cells by anti-candididal index in rats with type I diabetes. We found that the cytotoxicity activity of NK cells in IDDM groups significantly decreased compared to the control groups. The levels of interferonFACE="Symbol">-g (IFNFACE="Symbol">-g) in IDDM groups were slightly higher than in healthy controls. These results indicate that the changes of T H1 type cytokines such as IFNFACE="Symbol">-g and NK cell activity can play a role in the etiology of IDDM. The data may provide new strategies for the treatment of IDDM.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Células Matadoras Naturais
/
Citocinas
/
Diabetes Mellitus Experimental
/
Diabetes Mellitus Tipo 1
Tipo de estudo:
Estudo de etiologia
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
Gazi University/TR
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