Role of natural killer cells in antitumor resistance
ARBS annu. rev. biomed. sci
;
7: 127-148, 2005.
Artigo
em Inglês
| LILACS
| ID: lil-421297
ABSTRACT
Natural killer cells constitute a population of lymphocytes able to non-specifically destroy virus-infected and some kinds to tumor cells. Since this lytic activity was shown by non-immunized animals the phenomenon is denominated natural killer (NK) activity and contrasts with specific cytotoxicity performed by cytolytic T lymphocytes (CTLs) because it does not depends on MHC-restricted peptides recognition. In fact, the main feature of most functional receptors of NK cells (NKRs) is their ability to be inhibited by different kinds of class I MHC antigens. In the middle of the 1950, Burnet and Thomas forged the concept of tumor immunosurveillance and NK cells can be considered one of the main figures in this phenomenon both effector and regulatory functions. In the present review the early studies on the biology of NK cells were revisited and both their antitumor activity and dependence on the activation by cytokines are discussed
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Células Matadoras Naturais
/
Neoplasias
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
ARBS annu. rev. biomed. sci
Assunto da revista:
Biologia
Ano de publicação:
2005
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Estadual Paulista/BR
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