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Producción de anticuerpos IgG1 anti-glucuronoxilomanana en ratones resistentes a la criptococosis / Anti-glucuronoxylomannan IgG1 specific antibodies production in Cryptococcus neoformans resistant mice
Parra, Claudia; González, John Mario; Castañeda, Elizabeth; Fiorentino, Susana.
  • Parra, Claudia; Pontificia Universidad Javeriana. Facultad de Ciencias. Departamento de Microbiología. Grupo de Inmunobiología. Bogotá. CO
  • González, John Mario; University of South California. Keck School of Medicine. Department of Neurology. Los Angeles. US
  • Castañeda, Elizabeth; Instituto Nacional de Salud. Grupo de Inmunobiología. Bogotá. CO
  • Fiorentino, Susana; Pontificia Universidad Javeriana. Facultad de Ciencias. Departamento de Microbiología. Grupo de Inmunobiología. Bogotá. CO
Biomédica (Bogotá) ; 25(1): 110-119, mar. 2005. graf
Artigo em Espanhol | LILACS | ID: lil-421518
RESUMO
Cryptococcus neoformans is a widely disseminated fungus shown to be responsible for infections in individuals with impaired cell mediated immunity, such as patients with human immunodeficiency virus (HIV). Cryptococcus neoformans has a polysaccharide capsule composed of glucuronoxylomannan (GXM), which acts as a major virulence factor and is considered to be a thymus independent type-2 antigen (TI-2). Objective. In the current study, the production kinetics were evaluated for IgG subclasses specific for GXM, and assessed with the cross reactive antibodies to Streptococcus pneumoniae polysaccharide. In addition, spleen B cell subpopulations were quantified in murine models of cryptococcosis with different susceptibilities to the infection. Materials and methods. Antibodies were detected by ELISA at different time intervals after C. neoformans infection in moderately resistant (Balb/c), highly resistant (CBA/j) and susceptible (C57BL/6) mouse strains. B cells subpopulations were determined by flow cytometry analysis. Results. Early production of IgG1, described as protector antibodies, coincided with a decrease of the number of C. neoformans colony forming units in the lungs. Polysaccharide cross-reactive antibodies were detected in each of the three mouse strains. Antibody titers were highest in the susceptible strain (C57BL/6), a strain which also showed the highest proportion of splenic CD5+ B lymphocytes. In contrast, CBA/J mice showed the highest levels of CD43+ B. Conclusions. These findings suggest that IgG1 antibodies specific for GXM, are implicated in host protection against C. neoformans infection and may be regulated by CD43+ cells. They also suggest that cross reactivity antibodies are not important in the protection against C. neoformans infection
Assuntos
Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Imunoglobulina G / Cryptococcus neoformans / Farmacorresistência Fúngica / Glucuronatos Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Espanhol Revista: Biomédica (Bogotá) Assunto da revista: Medicina Ano de publicação: 2005 Tipo de documento: Artigo País de afiliação: Colômbia / Estados Unidos Instituição/País de afiliação: Instituto Nacional de Salud/CO / Pontificia Universidad Javeriana/CO / University of South California/US

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Imunoglobulina G / Cryptococcus neoformans / Farmacorresistência Fúngica / Glucuronatos Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Espanhol Revista: Biomédica (Bogotá) Assunto da revista: Medicina Ano de publicação: 2005 Tipo de documento: Artigo País de afiliação: Colômbia / Estados Unidos Instituição/País de afiliação: Instituto Nacional de Salud/CO / Pontificia Universidad Javeriana/CO / University of South California/US